There is the big fuss about DCIS and people are thinking of adding more therapies first of all to it, because there is a new one. DCIS is a risk factor for surgery. So, to keep it from coming back or from escalating to invasive cancer with the possibility of metastases seems a sensible thing if you have a safe and effective way of doing that.
We have focused our attention on the drug Tamoxifen. That's a bit paradoxical, because Tamoxifen has no effect on basically breast cancers. But Tamoxifen has two activities. It's a very interesting drug. It has an activity on receptors called estrogen receptors. And the way, in which it works for the most widely treated type of breast cancer, is that it blocks the estrogen receptors.
So, this trial was the largest trial that's ever been conducted in premenopausal women with hormone receptor positive breast cancer. There was the important difference between this trial and other trials.
Thank you for your interest in our research. We've got no conflicts of interest to disclose for this research. I would like to point out for those of you, who are interested in some more information about our study after the meeting, that I'm pleased to say that I have my study co-chair Jeanne Fleming in the audience. I also have Meredith Regan, who did the trial analysis here.
I'm 40. I've had two breast biopsies, one small and one large. My cells were abnormal, but not breast cancer. My choice is to start Tamoxifen or not. Should I?
One of the things that really interested me at San Antonio in 2018 was that we saw data looking at using Tamoxifen for women with ductal carcinoma in situ or the high-risk precancerous lesions, like lobular carcinoma in situ or atypical ductal hyperplasia. And it asked the question of Tamoxifen at five milligrams versus no therapy.
“Mothers have seen their children grow up. Grandmothers have seen their grandchildren grow up. That never happened before 1975, when chemotherapy was going to cure everything, and it didn't.
Hello everyone. I hope that everyone is safe during these crazy times and that everyone's social distancing. We're all doing the right thing and pretty soon, hopefully, the over there is. I would do a quick chat on Tamoxifen. That's the drug that some women go on after breast cancer. That is a maintenance drug and they'll prevent breast cancer to come back with the help of the drug.
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